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In pancreatic beta cells, GLP-1RA promotes the conversion of proinsulin to mature insulin by upregulating the expression of hormone converting enzymes PC1/3 and PC2, while reducing the proinsulin/insulin ratio and enhancing insulin biological activity

Interestingly, our own studies have found only Lys190 as the modified residue after oral administration of AX during 24 h (Garzon et al., 2014)

More insights on safe usage and interactions are available

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