Another consideration: NNMT is highly expressed in adipose tissue and liver but also present in the brain, kidneys, and vascular endothelium
If you have a very sensitive stomach, starting with a half-serving (one-half packet) twice a day can help your system adjust to the new amino acid profile without any changes in bowel frequency.
Deep Breathing Exercises Stress Reduction Practice diaphragmatic breathing to reduce stress-related digestive disruption and promote healthy gut-brain axis communication
According to 2021 animal research published in Food & Function, allulose helped to alter liver metabolites, including metabolites that are involved with the metabolic pathways of fatty acid -oxidation, cholesterol, and bile acid ( 18 )
Phase 3 results from the ORIGIN 3 trial, presented at the American Society of Nephrology Kidney Week in November 2025 and simultaneously published in The New England Journal of Medicine, showed a 46% reduction from baseline in proteinuria and a statistically significant 42% reduction compared to placebo
doi: 10.1016/j.celrep.2021.108761 141 XiaM.GonzalezP.LiC.MengG.JiangA.WangH.et al