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The variations in the signal (s) region and in the mid (m) greatly influence the effects of VacA, especially the s region variation which is associated with the vacuolating activity of VacA, whereas the m region of VacA determines the cell specificity of vacuolation by affecting the binding of VacA to the host cells

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Cysteine starvation or xCT blockade confers the opposite result and increases cellular NADPH pools

Subcutaneous injection produces rapid peak concentrations within 15-30 minutes followed by relatively quick clearance, potentially favoring daily administration to maintain consistent exposure in acute performance studies

10.1093/nar/gkz382 Nucleic Acids Res