weight loss medication glp 1 GLP-1 Agonists: A Comprehensive Overview With FDA approval of Wegovy

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A 2026 Washington University School of Medicine analysis of veterans with type 2 diabetes found that even brief interruptions of GLP-1 treatment -- as little as six months -- were associated with higher risk of heart attack, stroke, and death compared with continuous use

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A total of 19 participants (25,6%) discontinued treatment during the dose-escalation phase: nine participants lost follow-up, eight demonstrated poor adherence to treatment, one patient with ulcerative colitis developed mild gastric bleeding ( Supplementary Material ) and one was referred for bariatric surgery during the follow-up