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They are not a replacement for established orthopedic treatment

Abbott, K

Lancet 394(10193):121130 Wilding JP, Batterham RL, Calanna S et al (2021) Once-weekly semaglutide in adults with overweight or obesity

Ungaro R, Mehandru S, Allen P, Peyrin-Biroulet L, Colombel J

This article walks through three things in order: the no-human-data reality and what preclinical work does and doesn't establish, the theoretical oncological concern tied to the HGF/c-Met pathway, and the anecdotal adverse effects community sources describe