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Progressive multiple sclerosis: pathology and pathogenesis

Wang Y, Lu M, Xiong L, Fan J, Zhou Y, Li H, et al

It also prevents toxic oligomers and fibrils by stabilizing the proteins native conformation [72]

Recently, increasing attention has been focused on the application of metal complexes to catalyze the transformation of biological essential biomolecules into (cytotoxic) products or products that ultimately lead to cell death

Specifically, certain efflux transporters like P-gp on astrocytic end-feet, as well as transporters for anions, amino acids, and -amyloid, are downregulated

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