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10.18549/PharmPract.2019.4.1588 18 LiuY.ZhangX.ChaiS.ZhaoX.JiL

729 The expression of E3 ubiquitin ligase neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) was downregulated in MCAO/R models, and overexpressed m6A RNA methyltransferase METTL3 enhanced NEDD4L expression by methylating and stabilizing NEDD4L mRNA

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The translatability of especially rodent animal models, into humans has been really, really difficult, said Jacob Petersen, SVP and head of global nucleic acid therapies at Novo Nordisk