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Several providers offer significant discounts for paying annually instead of monthly

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doi: 10.1056/NEJMoa1607141 12 HernandezAFGreenJBJanmohamedSD'AgostinoRBSrGrangerCBJonesNPet al

Compare that to the 60/40 split some semaglutide studies show, and the difference over a 50-pound weight loss would be an additional 2-7 pounds of preserved lean mass

These new drugs could be life-changing for many who desperately need to lose weight for their health, especially if they can build new habits and optimise their nutrition

That said, neither format has published bioavailability data for tirzepatide specifically