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The key structural feature that distinguishes MT-2 from its linear predecessor Melanotan 1 is a lactam bridge, an internal bond that connects two amino acids within the chain and forces the peptide into a cyclic (ring) shape

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The beta coefficient () represents the size of the effect

Introduction Dopaminergic neurons, that project to many central nervous system (CNS) areas, have been implicated in a myriad of neurologic diseases including Parkinson's disease, dementia with Lewy bodies and Alzheimer's disease, which are all caused by neurodegeneration (Piggott et al., Experimental Facts: Dopaminergic Synapse In catecholaminergic neurons dopamine is synthesized in the cytosol near the synaptic vesicle (Cartier et al., Experimental Facts: Spontaneous Dopamine Oxidation Dopamine autoxidation occurs in an aqueous solution without enzymes such as MAO, catechol-O-methyltransferases (COMT) or diamine oxidases (DAO)