Notably, 31% of patients on GLP-1 RAs became completely headache-free at 6 months, versus only 8% of those on usual care (this difference did not remain significant after adjusting for weight loss)
Bottom Line: Build a Foundation of Strength, Not Just Weight Loss Weight loss is only one part of the equation
Mediation analyses revealed that 147 and 186 % of the excess NAFLD risk associated with l-carnitine and DMG, respectively, was mediated by TMAO (the P values for the mediating effects were 0021 and 0036, respectively)
This is considered a favorable alternative to orally bioavailable PDE5 inhibitors that show poor results in subjects with acute metabolic disease [10, 15, 16]
How This Study Compares to Other Meta-Analyses Every meta-analysis conducted since 2022 has confirmed the same conclusion: microneedling, alone or in combination with topical treatment, produces significantly better outcomes than topical treatment alone
Science 368 , 476477 (2020)