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For management of symptoms other than erythema, concomitant treatment must be considered.8 Agents for the management of inflammation or papules and pustules including metronidazole, azelaic acid, and ivermectin are sometimes used in conjunction with oxymetazoline or brimonidine for the management of rosacea symptoms.9 Despite the frequent need for combination therapy, at this time few randomized controlled trials exist on combination options for rosacea

PubMed Horowitz JD, Henry CA, Syrjanen ML, et al

A key feature is ECM degradation, which results from the upregulation of MMPs and ADAMTSs, leading to the breakdown of proteoglycans and collagen, ultimately causing structural damage to the intervertebral disc (36,37)

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Through its powerful antioxidative properties, L-theanine ameliorates vincristine-induced neuropathy in rats

A more recent study [23] included FEP subjects with up to 2 years of illness duration, while we recruited all subjects during the acute first episode (mean SOFAS score of 38.1)