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Key Drug Interactions and Health Considerations Contraindications : Both medications should not be used by individuals with a history of heart disease, overactive thyroid, glaucoma, or substance use disorder, and those who are pregnant or nursing

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Standard dosing involves a process called titration, which is a form of dose escalation designed to slowly introduce the drug to the body, helping to reduce side effects

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This approach bypasses the surface layers entirely, making it highly potent and immediate