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When B12 levels are low, symptoms like brain fog, irritability, low mood, and difficulty concentrating often follow

Amgen focuses on extended-half-life and differentiated peptide or biologic approaches that may reduce injection frequency, improving adherence in home settings

JAMA 303:14101418 Pratley RE, Nauck M, Bailey T et al (2010) Liraglutide vs sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial

The same rationale for B12 supplementation applies