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All in all, the prevention and treatment of PIPN still remain a significant and unmet clinical need, and consequently, high-quality researches toward related mechanisms, therapeutic drugs, and corresponding nanosystems are intensely expected for reliable and effective results

Interestingly, insulin is a common factor that activates Na + /K + -ATPase and increases its expression while also lowering blood glucose, consistent with DEN therapy

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A combination of cecum microbiome and metabolome in CUMS depressed rats reveals the antidepressant mechanism of traditional Chinese medicines: a case study of Xiaoyaosan