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03 Track results and adjust treatment Your doctor and care team monitor your results and adjust treatment for peak performance

Recent data reveals that GLP-1s are useful in heart disease, a condition that is currently the leading cause of death in men and women worldwide

The ominous octet (Defronzo model) includes: decreased muscle glucose uptake, increased hepatic glucose output, impaired incretin effect, alpha-cell hyperglucagonemia, increased renal glucose reabsorption (SGLT-2 upregulation), increased lipolysis (adipose), decreased central satiety signaling, and decreased beta-cell insulin secretion

Whether they persist or resolve with continued use is not yet fully characterised from long-term data

Fibroblasts are considered to play an important role in skin rejuvenation

Statements Author contributions MG and RP have contributed to the conception or design of the work, participated in the drafting of the manuscript and revising it critically for important intellectual content, approved the manuscript for publication and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved