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DSIP is a naturally occurring nonapeptide studied in sleep and neuroregulatory research

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Accelerated recovery in the -arrestin2 knockout was mimicked in wild type locus coeruleus by manipulations that should block arrestin upstream of its association with MOR (an intracellular GRK inhibitor) or endocytosis downstream of arrestin association (an intracellular dynamin inhibitor

Significant factor loadings were considered when 0.5

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Given that IGF can bypass IGF-IR to activate alternative signaling pathways, the stroma-derived IGF may contribute to resistance to anti-IGF-IR agents