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20 Semaglutide and liraglutide had significantly higher reporting odds ratios (RORs) compared to metformin or insulin for suicide ideation, depression/suicidal, suicide attempt, and completed suicide

10.1002/med.21485 Med Res Rev

Each type of research has strengths and limitations

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Taken together, GCGR agonism offers a promising yet complex strategy in cardiometabolic disease, as it promotes weight loss and energy expenditure while also increasing blood glucose, underscoring the need for dual- and triple-agonist approaches (GLP1R/GIPR/GCGR) that balance metabolic and CV effects