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The 2023 phase 2 double-blind, randomized controlled trial evaluating a GLP-1/GIP/glucagon receptor triagonist (retatrutide) in patients with the disease of obesity reported 24.2% weight loss at 48 weeks with 12 mg retatrutide

Graefes Arch Clin Exp Ophthalmol 1989;227:348-354

But "stronger" doesn't automatically mean "better for you." Side effects, insurance coverage, other health conditions and personal response all factor into which medication may be the better fit

The burden of obesity disproportionately affects economically disadvantaged groups, further entrenching health disparities in the US

For injectable forms, users often discuss minor injection-site reactions like bruising or swelling, though severe allergic reactions and copper toxicity are also potential risks