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In the case of alcohol the mechanism is well described: ethanol metabolism involving the CYP2E1 enzyme releases free radicals, and these reduce the level of reduced glutathione in the liver (Lieber, Drug Metabolism Reviews 2004, PMID 15554233)

Cyanocobalamin is a synthetic form of vitamin B12 that's commonly found in supplements

Expression of thymidylate synthase and glutathione-s-transferase pi in patients with esophageal squamous cell carcinoma

The OMM is permeable, mediates mitochondrial signal transmission, and carries molecules involved in fusion and fission, playing a crucial role in mitochondrial dynamics (Lin et al., 2022)

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In order to meet the criteria of being deemed "acceptable," the method must achieve a minimum score of 60 points