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The delayed stomach emptying can lower LES pressure slightly, making it easier for stomach acid to reflux upward

Its always dangerous to say, This time, its different. But this time, it really does seem different. Andersen adds: So it was a sort of slow realization after the data, approval, shortages and then it took off

Additional indications Knee osteoarthritis, sleep apnea, MASLD, cardiovascular outcomes, and chronic low back pain would follow based on their respective trial timelines This mirrors how Lilly handled tirzepatide: Mounjaro was approved for diabetes first (May 2022), followed by Zepbound for obesity (November 2023)

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Over-the-counter remedies may be appropriate in some cases, but should only be used after discussion with a pharmacist or GP: Oral rehydration salts (such as Dioralyte) are recommended for diarrhoea-related fluid loss Loperamide may be considered for short-term management of loose stools, but must be avoided if you have a fever, blood or mucus in your stools, or if antibiotic-associated diarrhoea (including Clostridioides difficile ) is suspected seek pharmacist or GP advice first For constipation, macrogol-based laxatives (such as Movicol) are a reasonable first-line option in line with NICE CKS guidance on constipation in adults

Consider trying a different batch from a quality source