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Reviewing these honestly shows a recurring pattern: strong mechanistic rationale, promising preclinical data, but inconsistent or inconclusive human results

S-glutathionylation disrupts the alignment of FAD and FMN, essential cofactors for eNOSs electron transport, resulting in superoxide production instead of NO (Zweier et al., 2011)

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The increased excretion of Na + and K + by the water extract is an important feature of a good diuretic, as it reduces the risk of hyperkalemia (547)

2e), and disrupts their juxtanuclear positioning (Fig