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KD is more effective than several novel anticonvulsant medications and families of affected children accept it because of its tolerability as well as its efficiency 3

In addition to the aforementioned remodelling of the metabolome in fatigue-associated diseases, including long COVID, acylcarnitines have emerged as important modulators of CNS function [29]: In both mice and humans, different classes of acylcarnitines have been found to be altered in either mouse models of depression or humans with MDD, with associations to symptom severity and also treatment response, as reviewed by Liu et al

L-Carnitine is a naturally occurring amino acid made in the liver, kidneys, and brain

FIGURE 1 3 TMAO and HF Gut microbiota and its metabolites are involved in the pathogenesis of HF (Zhang et al., 2015

+ Clinically Researched Our formulations are carefully constructed using a combined 70+ years of clinical research and experience in treating patients, conducted by our very own resident health care practitioners

doi:10.1038/s41374-018-0091-y Jin B, Ji F, Zuo A, et al