AMP research exploits their: Broad-spectrum bactericidal activity via membrane perturbation (colloido-osmotic mechanism, pore formation) Low resistance to bacterial selection (physical mechanism, little subject to mutation) Potential as antibiotic substitute in multi-resistance context Immunomodulatory activity : LL-37 stimulates leukocyte migration, neovascularisation, reepithelialisation In preclinical research, new-generation synthetic antimicrobial peptides (derivatives of magainin, indolicidin, protegrins) are tested on infected wound models
Note that this study used the parent compound epithalamin rather than the synthetic tetrapeptide Epithalon
Mol Aspects Med 30SI:112 Franklin CC, Backos DS, Mohar I, White CC, Forman HJ, Kavanagh TJ (2009) Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase
Human clinical trials have not been completed
The authors did not receive support from any organization for the submitted work
GHK-Cu works through copper-dependent enzymatic activation, TGF-beta signaling, antioxidant mechanisms, and broad gene expression modulation