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The complete primary sequence, including its site-specific modifications, must be confirmed with high-resolution peptide sequencing to support CMC filings and biosimilar characterization efforts

Muscle composition and fat loss often develop over 3 to 6 months

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During acute illness or dehydration, metformin should be temporarily stopped (follow 'sick day rules') and restarted when eating and drinking normally

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Genes in the turquoise module were broadly enriched in processes such as immune cell activation, lymphocyte differentiation, and immunological synapse formation ( Supplementary Figure 2C ), and KEGG analysis demonstrated significant enrichment in immune regulatory pathways closely related to RA pathogenesis, including Th17 cell differentiation, cytokinecytokine receptor interaction, and chemokine signaling pathway ( Supplementary Figure 2D )