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doi: 10.1073/pnas.1222878110 228 LevineBKroemerG

Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet

This makes it easier for the body to break down and use fats for energy rather than storing them, potentially contributing to weight loss

However, achieving weight loss solely by dietary and/or exercise interventions is very challenging for most individuals living with obesity [14]

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The double whammy increased body weight loss by about six percentage points compared with semaglutide in a clinical trial