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Our estimates of ATP consumption rate per NGV unit at 8 Hz firing in both young and aged states align well with literature estimates ( + /K + -ATPase expression in the aged brain are in line with a recent theory of non-canonical control of neuronal energy status ( Furthermore, the model shows that Na + /K + pump ATP use in the astrocyte is comparable to that of the neuron ( Figure 4C ), consistent with recent evidence (42)
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The repeated failures of A-targeted therapies highlight the need for a paradigm shift toward multi-targeted treatment approaches that address tau pathology, neuroinflammation, oxidative stress, mitochondrial dysfunction, and synaptic degeneration
