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KRAS mutation status is associated with enhanced dependency on folate metabolism pathways in non-small cell lung cancer cells

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Specifically, significant enrichment observed in pathways associated with energy metabolism, including tricarboxylic acid (TCA) cycle intermediates and fatty acid -oxidation and alterations in amino acid metabolism pathways, particularly those involving glutathione metabolism, emphasized the role of NAC in maintaining cellular redox homeostasis

SIRT1 has emerged as a key factor to enhance thermogenesis in BAT via activation of UCP-1 [33]

Avoid processed and fortified foods containing synthetic folic acid , high-sugar foods, commercial baked goods, alcohol, and inflammatory seed oils