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In a 12-month study of 339 Second Nature members published in JMIR Formative Research, members taking tirzepatide (Mounjaro) lost an average of 22.1% of their body weight, and those taking semaglutide (Wegovy) lost 17.1%, in line with the averages seen in the original clinical trials

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In a small tirzepatide report, TSH dropped in most participants within a relatively short time after treatment began, prompting the authors to suggest early monitoring