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No robust randomised study was identified comparing KLOW with placebo, standard care or any individual component

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Regarding the 2hPG reduction, sitagliptin (MD 2.88 mmol/L, 95% CrI 4.40 to 1.30) was better than placebo, while sitagliptin and omarigliptin were probably more effective than acarbose ( n = 2,775) (Figures S5AC)

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And the combination can lead to dehydration and electrolyte imbalances if vomiting or diarrhea becomes persistent, which creates secondary risks for kidney function and overall metabolic stability