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In 2024, ONeill et al

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One key action of IL-10 is to transform macrophages of an M1 inflammatory phenotype that produce high levels of pro-inflammatory cytokines and low levels of anti-inflammatory cytokines, to an M2b regulatory phenotype that produce low levels of pro-inflammatory cytokines and high levels of anti-inflammatory molecules [1, 26]

Nevertheless, a phase III study found no significant differences in cognition between rosiglitazone treatment and placebo in APOE-4-non-carriers or overall [37]

Kennedy, MD, MS