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These intermediates are often more reactive and potentially more harmful than the original toxin

(c) low high-density lipoprotein level less than 40 mg/dL in men and less than 50 mg/dL in women or on drug therapy for low high-density lipoprotein level (fibrates, nicotinic acid)

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In conclusion, ferroptosis is closely related to immune checkpoints in tumors and other diseases and may exert immune effects by blocking immune checkpoints

The protective effect of HO-1 in diabetic retinopathy is not only reflected in the inhibition of inflammation and oxidative stress but also promoted microglia polarization from the M1 state (pro-inflammatory) towards the M2 state (anti-inflammatory) [159]

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