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Gout, an inflammatory arthritic disorder which is the consequence of deposits of UA crystals, is the archetypal hyperuricemic disease and provides a model to investigate the relationship between blood UA and brain disease

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Several commenters, including many associations, urged CMS to use its special exceptions and adjustments authority under section 1886(d)(5)(I)(i) of the Act to implement a retrospective one-time adjustment for CY 2026 to account for the underestimation of the market basket updates over the last several years

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