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For instance, Eli Lilly is working on orforglipron, an oral GLP-1 drug that aims to provide a more flexible dosing regimen without the strict meal-timing requirements associated with oral semaglutide

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also evaluated the effect of incretin-based therapy (either GLP-1RAs or DPP-4i) on atherosclerotic plaques obtained from 52 patients with T2DM (of whom 24 were treated with GLP-1RAs or DPP-4i for a mean duration of 26 months) and 30 non-diabetic patients undergoing carotid endarterectomy [58]