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From a translational perspective, these findings raise the possibility of microbiome-based biomarkers and therapies in AD

In summary, periodontitis-associated oral microbiota may contribute to the pathogenesis and progression of depression by modulating gut microbiota composition and engaging immune-inflammatory pathways involving Th17 cell differentiation and microglia-mediated neuroinflammation

Heins AL, Weuster-Botz D

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The cDNA for SLC3A2 coding region was amplified from ZR-75-1 breast cancer cell line using standard RT-PCR and ligated into BamH I- EcoR I linearized pBabe-puro retroviral vector, generating the pBabe-puro-SLC3A2