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Based on the microglia transplantation approaches described (Table 2), it is appealing to hypothesize that bone marrow or hematopoietic cells could be modified ex vivo to express factors important for modulating an inflammatory response (such as IL-4, IGF-1, BDNF, GDNF) and/or blocking TLR/CD14 and then transplanted into ALS patients, taking advantage of the cells ability to migrate in the CNS (Fig
After 56 weeks, participants in the treatment group experienced a greater average reduction in baseline body weight than those in the placebo group
Additionally, glutathione plays a role in the detoxification of xenobiotics and endogenous compounds, which is particularly important in the treatment of heavy metal poisoning and other toxic exposures
Some combine multiple approaches