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PMID: 245 ZhaoYShenMWuLYangHYaoYYangQet al

Glutathione tackles this at a biological level by: Inhibiting tyrosinase activity to slow down melanin production Shifting melanogenesis from eumelanin (darker) to pheomelanin (lighter) Acting as an antioxidant to reduce the oxidative stress that triggers hyperpigmentation A 2025 systematic review in the International Journal of Dermatology confirms that oral glutathione at doses of 250 mg twice daily and 500 mg once daily showed a significant reduction in melanin index compared to placebo, particularly in sun-exposed areas like the face and wrists

Q2: What does it do for the skin

2c, Supplementary Fig

Additionally Vitamin C, undoes the harm caused by UV damage, improves skin elasticity and of course it lightens the skin improving pigmentation, blotches and darkness

Instead of mimicking GHRH, it binds to ghrelin receptors, triggering short, controlled pulses of growth hormone release