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Regular follow-up every 412 weeks during initiation and dose titration, then every 36 months once stable, ensures appropriate safety surveillance for this inadequately studied combination

Studies report modulation of NO synthase activity and interaction with NO-mediated tissue protection pathways, which may underlie its broad cytoprotective profile

Women with PCOS or perimenopause respond through mechanisms that extend beyond weight loss including direct reduction in ovarian androgen production and modulation of the LH/FSH ratio