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Exenatide once weekly for the treatment of type 2 diabetes mellitus: clinical results in subgroups of patients using different concomitant medications

A prospective study by Dao et al

Common gastrointestinal effects (Phase 2 NEJM) Retatrutide GI side effects at 12 mg in the Phase 2 NEJM trial Effect Nausea Rate at 12 mg Up to 25% Effect Diarrhea Rate at 12 mg Up to 23% Effect Vomiting Rate at 12 mg Up to 26% Effect Constipation Rate at 12 mg Up to 16% GI symptoms were most common during dose escalation and were usually mild to moderate

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The implication is clear