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When different levels of GLP-1 are dripped straight into peoples veins, you can see a dose-dependent reduction in both hunger and food intake

Using a model of streptozotocin diabetes in rats in vivo and HT-22 cells in vitro, it was shown that GLP-1RA liraglutide improves the cognitive abilities of rats with diabetes mellitus and can have a protective effect by reducing oxidative stress, suppressing the expression of -secretase (BACE1) and -secretase, as well as reducing the deposition of -amyloid by triggering signaling mechanisms associated with NF-kB and ERK1/2 [30]

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The first-night effect of sleep occurs over nonconsecutive nights in unfamiliar and familiar environments

Journal of Endocrinology and Metabolism, 107 (4), 621-629

Three insights stand out