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1.4 Whole exome sequencing (WES): justification and interpretation 1.4.1 Advantages over panels As mentioned in the introduction, WES enables the comprehensive analysis of ~19,500 protein-coding genes and, depending on the library (e.g., Agilent SureSelect CRE V4), approximately 5,500 additional clinically relevant loci, including splice sites, untranslated regions, lncRNAs, pseudogenes, regulatory elements and mtDNA (Petersen et al., 2017

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This prevents confounded outcomes and unclear side effects

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