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The ABCD of Obesity: An EASO Position Statement on a Diagnostic Term with Clinical and Scientific Implications

Jason Murphy, Head of Pharmacy at Chemist4U The bottom line Oral GLP-1s are delivering significant weight loss results in clinical trials, with many patients achieving the kind of weight reduction that can meaningfully improve long-term health

Clinical trials show average weight loss of 1522% of baseline body weight over 68 weeks with semaglutide

Patients with established cardiovascular disease, heart failure, or chronic kidney disease often benefit from GLP-1's pleiotropic effects beyond glucose control

[2] [3] However, missing an entire week means you're approaching the point where therapeutic drug concentrations fall below optimal levels