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Pre-2023 = traditional kratom

Key challenges for clinical translation include the lack of consistent benefit, as large RCTs and systematic meta-analyses have failed to demonstrate efficacy of prebiotics/probiotics in ICU patients despite encouraging signals in individual studies (Lee et al., 2023)

Lentinula edodes , commonly known as shiitake, ranks among the most widely cultivated edible mushrooms globally (3)

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Negative allosteric modulation of the glucagon receptor by RAMP2

GLP-1 (1 nmol/l) raised cAMP levels by about 40%, whereas the triagonist did not significantly increase cAMP above baseline, suggesting that Gs signalling may not be the primary pathway mediating triagonist-induced GSIS