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[7] In a Bayesian network meta-analysis of 48 randomized trials and nearly 28,000 participants, the dominant gastrointestinal events were nausea (about 21.5%), diarrhea (10.6%), vomiting (9.1%), and constipation (7.9%), with semaglutide carrying one of the highest constipation risks

These drugs bind to GLP-1 receptors on pancreatic beta cells, stimulating glucose-dependent insulin secretionmeaning they promote insulin release only when blood glucose levels are elevated

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Nonfatal and fatal cardiovascular disease events in CPAP compliant obstructive sleep apnea patients

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