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*Correspondence: Genhua Huang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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This helps to explain why highly processed sugary foods are easy to overconsume, as they do not stimulate the same satiety signals as whole foods, leaving us feeling less satisfied and more likely to continue eating them which can promote weight gain

Accordingly, restoration of nuclear SREBP-1c expression in liver-specific Chrebp defective mice normalized expression of some lipogenic genes, while not affecting glycolytic genes expressing

GLP-1 (like semaglutide) activates only the GLP-1 receptor