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Meanwhile, new competitive threats continued to surface: in 2025, Lilly unveiled impressive results for an oral GLP-1 pill (orforglipron) that in trials matched injectable Ozempic's efficacy, news that instantly added ~$100 billion to Lilly's market cap

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10.1016/0197-2456(95)00134-4 89 JansenF.YangX.FranklinB

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Additionally, patients with MS show a selective downregulation of the protein annexin A1 in the plasma and cerebral microvessel endothelia and annexin A1 knockout mice have increased BBB permeability [133]