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Topical cosmetic peptides like GHK-Cu, Matrixyl, and argireline are similarly non-concerns

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10.1016/j.yexmp.2024.104904 23

The thicker, cream-based textures of masks create an occlusive barrier that enhances penetration of the Pure Copper peptide deep into the scalp tissue, while additional ingredients such as hyaluronic acid, ceramides, and botanical extracts provide comprehensive scalp nourishment

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Interestingly, L585 could only be replaced with an amino acid having similar physiochemical properties, including isoleucine, methionine, and valine, without negatively affecting FcRn binding 64