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Covarrubias, A

Sedentary behavior: While semaglutide works without exercise, a completely sedentary lifestyle limits results by allowing muscle loss, reducing daily energy expenditure, and missing the metabolic benefits of physical activity

( Epub 2001 Sep 26 )

The question arises if mtDNA mutations will increase in frequency through the effect of human migration

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But adding a second pathway amplifies the overall effect