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The genes affected by semaglutide included markers of inflammation and plaque stability that are associated with leukocyte recruitment [e.g., interleukin-1 (IL-1) receptor antagonist, IL-6, monocyte chemoattractant protein (CCL2), OPN], leukocyte adhesion [selectin E, vascular cell adhesion molecule-1 (VCAM1)], leukocyte extravasation and plaque stability (e.g., MMP3, MMP13, CCL2), and plaque rupture and hemorrhage (CD163)
Blood J 121:8 Zanoni TB, Tiago M, Faio-Flores F, Barros SBM, Bast A, Hageman G, Oliveira DP, Maria-Engler SS (2014) Basic red 51, a permitted semipermanent hair dye, is cytotoxic to human skin cells: studies in monolayer and 3D skin model using human keratinocytes (HaCaT)
Humana doesnt currently cover Wegovy for weight loss in adults without established cardiovascular disease or MASH
Combining with tissue repair peptides like BPC-157 might support gut health during the GI stress of GLP-1 therapy
A recent study investigated the influence of green tea on tears in individuals with good health