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Participants were randomly assigned to receive weekly injections of retatrutide at doses of 1 mg, 4 mg, 8 mg or 12 mg, or a placebo for 48 weeks

Berry SD, Kiel DP

Tirzepatide (Mounjaro) may cause thyroid tumors, including cancer of the thyroid

These agents mimic the biological action of the native incretin hormone GLP-1 but are structurally modified to resist degradation by the enzyme dipeptidyl peptidase 4 (DPP-4), thereby extending their half-life and duration of action (Zheng et al., 2024

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