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The hypothalamus, a key target of leptin action, is rich in LepR in the arcuate nucleus

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DOI: Published online: April 25, 2016 Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

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Persistent symptoms may warrant a dose adjustment, a temporary acid-suppressing medication (like omeprazole), or investigation into whether an underlying condition like gastroesophageal reflux disease (GERD) is being unmasked by the tirzepatide's effects

Chang, C.-H., Tsai, W.-C., Hsu, Y.-H., & Pang, J.-H